3-Amino-5-methylisoxazole → HCID 178428624, compound

HRID 1155051Notes

Reaction equation

HRID 1155051 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[C:12]([C:13](Cl)=[O:14])=[C:11]([OH:16])[C:10]2[C:5](=[C:6]([C:17]([F:20])([F:19])[F:18])[CH:7]=[CH:8][CH:9]=2)[N:4]=1.[NH2:23][C:24]1[CH:28]=[C:27]([CH3:29])[O:26][N:25]=1>>[F:1][C:2]([F:22])([F:21])[C:3]1[C:12]([C:13]([NH:23][C:24]2[CH:28]=[C:27]([CH3:29])[O:26][N:25]=2)=[O:14])=[C:11]([OH:16])[C:10]2[C:5](=[C:6]([C:17]([F:20])([F:19])[F:18])[CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 661723-Amino-5-methylisoxazoleHCID 178521117HCID 178521117, compound

Product 1

HCID 178428624HCID 178428624, compoundYield 48.6%

Procedure

Using the procedure of Example 2, 27.2 g of 2,8-bis-(trifluoromethyl)-4-hydroxy-3-quinoline-carboxylic acid chloride and 6.38 g of 3-amino-5-methyl-isoxazole were reacted to obtain 12.8 g of 2,8-bis-(trifluoromethyl)-4-hydroxy-N-(5-methyl-isoxazol-3-yl)-3-quinoline-carboxamide melting at 216° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-8eb70b02b81043e883926dfef10b3309
Source dataset
uspto-grants-1981_11
Patent number
US04299831

Reaction notes

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