1-Methyl-1H-imidazol-2-amine → HCID 178480599, compound

HRID 1155052Notes

Reaction equation

HRID 1155052 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[C:12]([C:13](Cl)=[O:14])=[C:11]([OH:16])[C:10]2[C:5](=[C:6]([C:17]([F:20])([F:19])[F:18])[CH:7]=[CH:8][CH:9]=2)[N:4]=1.[NH2:23][C:24]1[N:25]([CH3:29])[CH:26]=[CH:27][N:28]=1>>[F:1][C:2]([F:22])([F:21])[C:3]1[C:12]([C:13]([NH:23][C:24]2[N:25]([CH3:29])[CH:26]=[CH:27][N:28]=2)=[O:14])=[C:11]([OH:16])[C:10]2[C:5](=[C:6]([C:17]([F:20])([F:19])[F:18])[CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 5663211-Methyl-1H-imidazol-2-amineHCID 178521117HCID 178521117, compound

Product 1

HCID 178480599HCID 178480599, compoundYield 33.9%

Procedure

Using the procedure of Example 1, 2,8-bis-(trifluoromethyl)-4-hydroxy-3-quinoline-carboxylic acid chloride and 2-amino-N-methyl-imidazole were reacted to obtain a 33.9% yield of 2,8-bis-(trifluoromethyl)-4-hydroxy-N-(1-methyl-1H-imidazol-2-yl-)-3-quinolinecarboxamide melting at 259° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b46d9828454a47bdb54a83d9da232139
Source dataset
uspto-grants-1981_11
Patent number
US04299831

Reaction notes

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