Phosphorus pentachloride → HCID 12471709, compound

HRID 1155055Notes

Reaction equation

[F:1][C:2]([F:17])([F:16])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)=O.P(Cl)(Cl)(Cl)(Cl)[Cl:19]>>[F:1][C:2]([F:17])([F:16])[C:3]([Cl:19])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1

Participants

Reactant 2

HCID 24819Phosphorus pentachloride

HCID 101316Acetanilide, 2,2,2-trifluoro-3'-(trifluoromethyl)-

Product 1

HCID 12471709HCID 12471709, compoundYield 24.4%

Conditions

Temperature: 80 °C

Procedure

An intimate mixture of 120.3 g of the product of Step A and 106.6 g of phosphorus pentachloride was heated at 80° C. under an inert atmosphere for 5 hours and phosphorus oxychloride was distilled at 25° C. at 40 mm Hg to obtain 31.44 g of 2,2,2-trifluoro-N-(3-trifluoromethylphenyl)-ethanimidoyl chloride with a boiling point of 75° C. at 30 mm Hg.

Workup

distillationphosphorus oxychloride was distilled at 25° C. at 40 mm Hg

Sources & evidence

ORD record: ord-9aeaa078efbd453db55ff71b12280b69
Source dataset: uspto-grants-1981_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04299831

Reaction notes

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