Sodium Hydroxide → HCID 178524537, compound

Participants

Reaction Steps

A mixture of 21.38 g of the product of Step D, 300 ml of ethanol and 60.5 ml of sodium hydroxide solution was refluxed with stirring for 7 hours and the ethanol was then distilled under reduced pressure at 40° C. The residue was taken up in about 300 ml of water and the pH was adjusted to 1 by addition of 20% hydrochloric acid. The mixture was vacuum filtered and the recovered product was washed with water and was taken up in 350 ml of ether. The organic phase was washed with water, dried and evaporated to dryness under reduced pressure to obtain 18.65 g of 2,7-bis-(trifluoromethyl)-4-hydroxy-3-quinoline-carboxylic acid melting at 240° C.

Provenance & Evidence