Thionyl Chloride → HCID 178521116, compound

Participants

Reaction Steps

31.89 g of thionyl chloride were added to a suspension of 17.246 g of the product of Step E in 535 ml of anhydrous benzene and the mixture was refluxed for 105 minutes and was then evaporated to dryness under reduced pressure at 40° C. The residue was taken up in benzene and the solution was evaporated to dryness under the same conditions to obtain 18.62 g of 2,7-bis-(trifluoromethyl)-4-hydroxy-3-quinolinecarboxylic acid chloride.

Provenance & Evidence