反应详情

A mixture of 5.5 g of 4,5-diaminopyrimidine and 10.9 g of 2,4-dimethoxy-benzoic acid was triturated in a mortar. The mixture was added to 100 ml of phosphorus oxychloride and refluxed for one hour. The phosphorus oxychloride was decomposed under stirring into water, and the solution obtained was neutralized with ammonia after filtration. The precipitated product was recrystallized from water and ethanol/cyclohexane (volume ratio of 1:3).

1. customwas triturated in a mortar
2. additionThe mixture was added to 100 ml of phosphorus oxychloride
3. temperaturerefluxed for one hour
4. customthe solution obtained
5. filtrationafter filtration
6. customThe precipitated product was recrystallized from water and ethanol/cyclohexane (volume ratio of 1:3)