Ammonia → 1H-Purine, 8-(2,4-dimethoxyphenyl)-

HRID 1155064Notes

Reaction equation

HRID 1155064 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:12]=1[C:13](O)=O.N>>[CH3:9][O:10][C:11]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:12]=1[C:13]1[NH:8][C:7]2[C:2](=[N:3][CH:4]=[N:5][CH:6]=2)[N:1]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 70522,4-Dimethoxybenzoic acidHCID 837034,5-Diaminopyrimidine

Product 1

HCID 30599121H-Purine, 8-(2,4-dimethoxyphenyl)-

Procedure

A mixture of 5.5 g of 4,5-diaminopyrimidine and 10.9 g of 2,4-dimethoxy-benzoic acid was triturated in a mortar. The mixture was added to 100 ml of phosphorus oxychloride and refluxed for one hour. The phosphorus oxychloride was decomposed under stirring into water, and the solution obtained was neutralized with ammonia after filtration. The precipitated product was recrystallized from water and ethanol/cyclohexane (volume ratio of 1:3).

Workup

  1. customwas triturated in a mortar
  2. additionThe mixture was added to 100 ml of phosphorus oxychloride
  3. temperaturerefluxed for one hour
  4. customthe solution obtained
  5. filtrationafter filtration
  6. customThe precipitated product was recrystallized from water and ethanol/cyclohexane (volume ratio of 1:3)

Sources & evidence

ORD record
ord-6a90d463b66a4dcfa829660cb11e8926
Source dataset
uspto-grants-1981_11
Patent number
US04299834

Reaction notes

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