HCID 20562715, compound → HCID 20562713, compound

Participants

Reaction Steps

An amount of 7.5 g of 4-amino-5-(3,4-dimethoxy-benzoylamino)-pyrimidine was refluxed in 100 ml of phosphorus oxychloride for six hours. After evaporation and pouring on water, the solution was neutralized by means of potassium carbonate. The solution was evaporated to dryness, and the residue was extracted with boiling ethanol. The alcoholic solution was evaporated, and the remaining product was purified over silicagel (eluate: methylene chloride/ethanol in a volume ratio of 19:1).

Provenance & Evidence