2-Ethoxy-4-(methylsulfanyl)benzoic acid → HCID 70550971, compound

Participants

Reaction Steps

Three grams of 2-ethoxy-4-methylmercapto-benzoic acid and 2.2 g of 4,5-diamino-pyrimidine hydrochloride were refluxed in 30 ml of phosphorus oxychloride for three hours. The reaction mixture was poured on ice and then made ammoniacal, and the supernatant solution was decanted from the semicrystalline residue. After dissolution in methanol and filtering off from the insoluble products, the residue was purified over a silicagel column (eluate: methylene chloride/ethanol in volume ratio of from 100:0 to 98:2). The hydrochloride was precipitated from acetone with ethereal hydrochloric acid.

Provenance & Evidence