HCID 54013766, compound → 5-Hydroxy-N-(1-{2-[hydroxy(imino)methyl]pyrrolidin-1-yl}-1-oxopentan-2-yl)-3,4-dihydro-2H-pyrrole-2-carboximidic acid

Participants

Reaction Steps

1.42 g (3.1 mmoles) of Z-Glp-Nva-Pro-NH2 are dissolved in 30 ml of methanol. 0.2 g of a 10% palladium-on-carbon catalyst are added to the solution, and hydrogen is bubbled through the mixture for 30 minutes. The catalyst is filtered off, the filtrate is evaporated, and the amorphous, solid residue is triturated with ether. The resulting crude product is dissolved in water, the solution is decolourized, filtered, and the clear filtrate is freeze-dried. 0.95 g (94%) of Glp-Nva-Pro-NH2 are obtained; Rf4 =0.36, [α]D25 =-87.0° (c=1%, in acetic acid). Amino acid analysis: Glu: 0.97 (1.0), Nva: 1.09 (1.0), Pro: 1.00 (1.0).

Provenance & Evidence