HCID 131712538, compound → HCID 13312515, compound

Participants

Reaction Steps

2.67 g (6 mmoles) of Z-Glp-Abu-Pro-NH2 are dissolved in 100 ml of acetic acid. 0.5 g of a 10% palladium-on-carbon catalyst are added to the solution, and hydrogen is bubbled through the mixture for one hour. The catalyst is filtered off, the filtrate is evaporated, and the residue is triturated with ether. The resulting 1.82 g of amorphous crude product are dissolved in water, the solution is decolourized, filtered, and the clear filtrate is freeze-dried. 1.70 g (91%) of Glp-Abu-Pro-NH2 are obtained; Rf4 =0.24, [α]D25 =-102.5° (c=1%, in acetic acid).

Provenance & Evidence