HCID 131712539, compound → 5-Oxo-L-prolyl-3-cyclohexyl-L-alanyl-L-prolinamide

Participants

Reaction Steps

3.07 g (6 mmoles) of Z-Glp-Cha-Pro-NH2 are dissolved in 60 ml of ethanol, 0.6 g of a 10% palladium-on-carbon catalyst are added, and hydrogen is bubbled through the mixture for 2 hours. The catalyst is filtered off, the filtrate is evaporated, and the residue is triturated with ether. 2.15 g (95%) of Glp-Cha-Pro-NH2 are obtained as an amorphous solid; Rf4 =0.50, [α]D25 =-70.9° (c=1%, in acetic acid).

Provenance & Evidence