HCID 131712541, compound → HCID 13312523, compound

Participants

Reaction Steps

4.02 g (8 mmoles) of Z-Glp-Ser(tBu)-Pro-NH2 are dissolved in 160 ml of methanol, 0.8 g of a 10% palladium-on-carbon catalyst are added, and hydrogen is bubbled through the mixture for 30 minutes. The catalyst is filtered off, the filtrate is evaporated, and the residue is covered with ether and allowed to crystallize. The crystals are filtered off to obtain 2.50 g (85%) of Glp-Ser(tBu)-Pro-NH2 ; m.p.: 186°-187° C., Rf4 =0.45, [α]D25 =-60.8° (c=1%, in acetic acid). Amino acid analysis: Glu: 1.03 (1.0), Ser: 1.00 (1.0), Pro: 1.00 (1.0).

Provenance & Evidence