HCID 178513897, compound → HCID 178513939, compound

Participants

Reaction Steps

2.1 g (4 mmoles) of Z-Gln-His-HPro-NH2 are dissolved in 40 ml of acetic acid, 0.4 g of a 10% palladium-on-carbon catalyst are added, and hydrogen is bubbled through the mixture for one hour. The catalyst is filtered off, the filtrate is heated to 60°-70° C., maintained at this temperature for 30 minutes, and then evaporated in vacuo. The resulting crude product is subjected to ion exchange and purified as described in Step 5 of Example 15. 618 mg (56%) of Glp-His-HPro-NH2 are obtained; Rf4 =0.08, [α]D25 =-24.0° (c=1%, in methanol). Amino acid analysis: Glu: 0.97 (1.0), His: 1.00 (1.0), HPro: 0.91 (1.0).

Provenance & Evidence