Ethanesulfonic acid → HCID 12764425, compound

Participants

Reaction Steps

A solution of ethanesulfonic acid (24 g.) in isopropyl alcohol (80 ml.) was added with warming (40°-50° C.) to a solution of 4-cyclopropylmethyl-9-amino-3,4,5,6-tetrahydro-2H-1,5-methano-1,4-benzodiazocine (26.9 g.) in methanol (120 ml.), affording 4-cyclopropylmethyl-9-amino-3,4,5,6-tetrahydro-2H-1,5-methano-1,4-benzodiazocine diethanesulfonate in two crops (34 g., m.r. 221-225° C.; 14 g., m.r. 211°-219° C.), the second of which was recrystallized from methanol-isopropyl alcohol (10 g., m.r. 221°-224° C.).

Provenance & Evidence