Hydrochloric Acid → HCID 20562573, compound

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Reaction Steps

A mixture of 4-acetyl-9-nitro-3,4,5,6-tetrahydro-2H-1,5-methano-1,4-benzodiazocine (37.5 g.) and concentrated hydrochloric acid (200 ml.) was heated for four hours on a steam bath, then concentrated. The solid residue was slurried with ethanol (100 ml.) and filtered affording 9-nitro-3,4,5,6-tetrahydro-2H-1,5-methano-1,4-benzodiazocine hydrochloride (30 g., m.r. 255°-260° C.), the hydrochloride salt of the compound of Formula III wherein Q* is hydrogen. The salt was converted with dilute aqueous sodium hydroxide into the free base, a syrupy brown oil (17.5 g.).

Provenance & Evidence