Acetic Anhydride → HCID 12764438, compound

Participants

Reaction Steps

A mixture of 4-cyclopropylmethyl-9-amino-3,4,5,6-tetrahydro-2H-1,5-methano-1,4-benzodiazocine (3 g.), acetic anhydride (10 ml.) and pyridine (25 ml.) was let stand for two hours at room temperature, then concentrated to dryness. The residue was partitioned between aqueous ammonia and chloroform. The chloroform layer was dried and concentrated to dryness. Recrystallization of the residue from ether afforded 4-cyclopropylmethyl-9-acetamido-3,4,5,6-tetrahydro-2H-1,5-methano-1,4-benzodiazocine (2.5 g., m.r. 131°-132° C.), the compound of Formula V wherein Q is cyclopropylmethyl and R"CONH is acetamido.

Provenance & Evidence