4-Nitro-3-(trifluoromethyl)aniline → HCID 22818468, compound

HRID 1155148Notes

Reaction equation

HRID 1155148 reaction equation
[C@@H:1]1([C:10](Cl)=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][C@H:2]1[C:7](Cl)=[O:8].[F:13][C:14]([F:26])([F:25])[C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][C:21]=1[N+:22]([O-:24])=[O:23])[NH2:18]>C1C=CC=CC=1>[F:13][C:14]([F:25])([F:26])[C:15]1[CH:16]=[C:17]([NH:18][C:10]([C@@H:1]2[CH2:6][CH2:5][CH2:4][CH2:3][C@H:2]2[C:7]([NH:18][C:17]2[CH:19]=[CH:20][C:21]([N+:22]([O-:24])=[O:23])=[C:15]([C:14]([F:13])([F:25])[F:26])[CH:16]=2)=[O:8])=[O:11])[CH:19]=[CH:20][C:21]=1[N+:22]([O-:24])=[O:23]

Participants

4

Reactant 2

HCID 949554-Nitro-3-(trifluoromethyl)anilineHCID 12501622(1R,2R)-Cyclohexane-1,2-dicarbonyl dichloride

Product 1

HCID 22818468HCID 22818468, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Reflux a mixture of 16.73 g (0.08 moles) of trans-1,2-cyclohexane dicarboxylic acid chloride and 32.96 g (0.16 moles) of 3-trifluoromethyl-4-nitroaniline in 250 ml of benzene for 1.5 hours. Isolate the solid product of this example by filtering, washing well with hot benzene followed by ether and obtain analytically pure material by recrystallization from benzenemethanol, mp 249.5°-251° C. (dec.).

Workup

  1. temperatureReflux
  2. customIsolate the solid product of this example
  3. filtrationby filtering
  4. washwashing well with hot benzene
  5. customobtain analytically pure material
  6. customby recrystallization from benzenemethanol, mp 249.5°-251° C. (dec.)

Sources & evidence

ORD record
ord-cfd44ccd84d74125ba20c57677deca2d
Source dataset
uspto-grants-1981_11
Patent number
US04299845

Reaction notes

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