Thiourea → 2,2,2-Trichloroethyl 2-methyl-7-[2-hydroxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-cephem-4-carboxylate

HRID 1155166Notes

Reaction equation

HRID 1155166 reaction equation
[CH3:1][CH:2]1[CH:7]=[C:6]([C:8]([O:10][CH2:11][C:12]([Cl:15])([Cl:14])[Cl:13])=[O:9])[N:5]2[C:16](=[O:28])[CH:17]([NH:18][C:19](=[O:27])[C:20](=[N:25][OH:26])[C:21](=O)[CH2:22]Br)[C@H:4]2[S:3]1.[NH2:29][C:30]([NH2:32])=[S:31]>C(O)C>[CH3:1][CH:2]1[CH:7]=[C:6]([C:8]([O:10][CH2:11][C:12]([Cl:15])([Cl:14])[Cl:13])=[O:9])[N:5]2[C:16](=[O:28])[CH:17]([NH:18][C:19](=[O:27])[C:20](=[N:25][OH:26])[C:21]3[N:29]=[C:30]([NH2:32])[S:31][CH:22]=3)[C@H:4]2[S:3]1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 178427241HCID 178427241, compound

Product 1

HCID 1317114982,2,2-Trichloroethyl 2-methyl-7-[2-hydroxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-cephem-4-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2,2,2-trichloroethyl 2-methyl-7-(2-hydroxyimino-3-oxo-4-bromobutyramido)-3-cephem-4-carboxylate (a mixture of syn and anti isomers) (0.51 g.) in ethanol (10 ml.) was added thiourea (0.068 g.), and the mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated under reduced pressure. To the residue were added ethyl acetate and water with stirring, and the ethyl acetate layer was separated. The remaining aqueous layer was adjusted to pH 7 and extracted with ethyl acetate. The ethyl acetate layer and extract were combined together, washed with water, dried over magnesium sulfate and then concentrated. The residue was pulverized in diethyl ether, collected by filtration and then dried to give pale brown powder of 2,2,2-trichloroethyl 2-methyl-7-[2-hydroxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-cephem-4-carboxylate (syn isomer), which can be represented as 2,2,2-trichloroethyl 2-methyl-7-[2-hydroxyimino-2-(2-imino-2,3-dihydrothiazol-4-yl)acetamido]-3-cephem-4-carboxylate (syn isomer), mp 175° to 178° C. (dec.).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionTo the residue were added ethyl acetate and water
  3. stirringwith stirring
  4. customthe ethyl acetate layer was separated
  5. extractionextracted with ethyl acetate
  6. extractionThe ethyl acetate layer and extract
  7. washwashed with water
  8. dry with materialdried over magnesium sulfate
  9. concentrationconcentrated
  10. filtrationcollected by filtration
  11. customdried

Sources & evidence

ORD record
ord-633f2f14451743a88aea1e48b4890bb4
Source dataset
uspto-grants-1981_11
Patent number
US04299829

Reaction notes

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