HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1155199Generated: November 1, 2026
Sodium borohydride → 5-Chloro-2'-fluoro-2-iodobenzhydrol
https://huagongshe.com/reaction/1155199
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | (5-Chloro-2-iodophenyl)(2-fluorophenyl)methanone | HCID 12948263 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Chloro-2'-fluoro-2-iodobenzhydrol | HCID 20563122 | — |
Reaction Steps
A mixture of 54 g (0.15 mole) of 5-chloro-2'-fluoro-2-iodobenzophenone and 28.4 g (0.75 mole) of sodium borohydride in 1000 ml of ethanol was stirred at 0° C. for 15 min. The solution was diluted with water and extracted with ether. The ether solution was washed with water, dried over anhydrous sodium sulfate, and concentrated at reduced pressure to give a deep yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04299971 |
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| Source dataset | uspto-grants-1981_11 |
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| ORD ID | ord-f7131cc2de7544ac8bff8eaff6577b65 |
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| Source note | uspto-grants-1981_11 |
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