N,N'-Dimethylurea → 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one

Participants

Reaction Steps

Dimethylurea (2 moles, 176 parts) and glyoxal (2 moles, 290 parts of 40% aqueous solution) are mixed and the pH adjusted to 7 with sodium hydroxide. The reaction mixture is stirred at room temperature for several hours and the resulting white solid is filtered, washed with methanol and dried. White crystals, m.p. 140° C., are obtained in fine yield.

Provenance & Evidence