Dimethyl Sulfate → HCID 12790655, compound

Participants

Reaction Steps

To a solution of N-(diethylaminoethyl)-5-methanesulfonamido-2-methoxybenzamide in acetone are added dimethyl sulfate and potassium carbonate. The resultant mixture is refluxed for 2 hours. After evaporating the solvent, the residue is mixed with water and shaken with methylene chloride. The organic layer is washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuum. The residue is washed with isopropyl ether to give N-(diethylaminoethyl)-2-methoxy-5-(N-methyl-methanesulfonamido)benzamide as crystals melting at 48°-50° C.

Provenance & Evidence