Maleic Anhydride → (2Z)-4-(Hexadecylamino)-4-oxo-2-butenoic acid

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Reaction Steps

19.6 g of maleic acid anhydride are dissolved in 500 ml of toluene at 90° C. The temperature is maintained at 90° C. while 48.2 g of hexadecylamine, dissolved in 200 ml of toluene are added dropwise within 45 minutes. After one more hour at 90° C. followed by cooling, the resulting precipitate is suction filtered and washed with methanol. 44.5 g of N-hexadecylmaleic amide melting at 101° to 102.5° C. are obtained.

Provenance & Evidence