Cyanogen Chloride → 5-Chloro-1H-tetrazole-1-acetic acid ethyl ester

Participants

Reaction Steps

A mixture of 130 g. (1 mole) of ethyl azidoacetate prepared as described in Part A and 96 g. (1.56 mole) of cyanogen chloride was heated at a temperature of 125° C. for 20 hours. After the reaction mixture had cooled, the reaction product mixture was dissolved in ethyl acetate, and the solution was filtered and evaporated in vacuo yielding a yellow crystalline mass of product. The yellow crystals were recrystallized from aqueous ethyl alcohol and gave 149 g. (78% yield) of ethyl 5-chloro-1H-tetrazol-1-ylacetate as pale yellow crystals melting at about 57°-60° C.

Provenance & Evidence