反应详情

温度

45 °C

The reaction mixture from Stage A was boiled so as to drive off the isopropyl acetate solvent. A solution of 100 g of sodium hydroxide in 100 ml of water was added to the residue, and the whole was refluxed for 2 hours. After cooling to 45° C., the product was extracted with four 270 ml portions of isopropyl acetate. The isopropyl acetate was then distilled off and the product recrystallized from toluene to give 100 g (63% of theoretical) of 97-98% pure 2-amino-benzyl alcohol; m.p. 83°-83.5° C.

1. temperaturethe whole was refluxed for 2 hours
2. extractionthe product was extracted with four 270 ml portions of isopropyl acetate
3. distillationThe isopropyl acetate was then distilled off
4. customthe product recrystallized from toluene