Ethanolamine → HCID 12784115, compound

HRID 1155396Notes

Reaction equation

HRID 1155396 reaction equation
C(O[C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH3:24])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1Cl)=[O:5])C.[NH2:26][CH2:27][CH2:28][OH:29]>>[CH2:23]([N:20]1[C:9]2[N:10]=[C:11]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:12]=[CH:13][C:8]=2[C:7]([NH:26][CH2:27][CH2:28][OH:29])=[C:6]([C:4]([NH:26][CH2:27][CH2:28][OH:29])=[O:5])[C:21]1=[O:22])[CH3:24]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 12784117HCID 12784117, compound

Product 1

HCID 12784115HCID 12784115, compound

Procedure

To 2 g. (0.0056 mole) of 5-chloro-7,8-dihydro-8-ethyl-7-oxo-2-phenylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (prepared by the method of the first paragraph of Example 3) was added 20 ml. of 2-aminoethanol and this mixture was heated at reflux for 1.5 hours. The reaction mixture was chilled in ice and the product collected on a filter and recrystallized from ethanol to give 1.7 g. of product.--m.p. 250°-253° C.

Workup

  1. additionwas added 20 ml
  2. temperatureat reflux for 1.5 hours
  3. temperatureThe reaction mixture was chilled in ice
  4. customthe product collected on
  5. filtrationa filter
  6. customrecrystallized from ethanol
  7. customto give 1.7 g

Sources & evidence

ORD record
ord-367ed8d3f8c14681b9df2b67dbff1f23
Source dataset
uspto-grants-1981_11
Patent number
US04301281

Reaction notes

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