Hydrochloric Acid → 1-(2'-Fluoro[1,1'-biphenyl]-4-yl)ethanone

Participants

Reaction Steps

A solution of 200 g. of 2-fluorobiphenyl in 1500 ml. of CS2 was cooled to 0°-5° C. and treated with 200 g. of aluminum chloride over 140 minutes and then with 113 g. of acetyl chloride over 165 minutes. The mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was then poured carefully into ice and hydrochloric acid, and organic material was extracted with a mixture of diethyl ether and ethyl acetate. The organic extract was washed with water, 10% sodium hydroxide, and water, and dried over sodium sulfate. Evaporation of the solvents in vacuo and recrystallization of the solid residue from hexane gave (4'-(2-fluorophenyl)acetophenone. This was recrystallized from hexane to give two crops Crop one, 173 g., m.p. 84.5°-86.5° C.

Provenance & Evidence