HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)- → 4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)- | HCID 155242 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol | HCID 155241 | — |
Reaction Steps
The product from (c) (1.7 g) and excess of pyridine hydrochloride were heated together for 8 hours at 180° C. The mixture was cooled, diluted with water and 2-molar hydrochloric acid, and extracted with ether. The extracts were dried and evaporated to yield an oil identified as the required hydroxy compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04302242 |
| Source dataset | uspto-grants-1981_11 |
| ORD ID | ord-b2b93f581afd4ba08de951bf7d3c848f |
| Source note | uspto-grants-1981_11 |