Water → HCID 73164534, compound

HRID 1155484Notes

Reaction equation

HRID 1155484 reaction equation
[N:1](=[C:3]([CH:6]([CH3:8])[CH3:7])[C:4]#N)[OH:2].[OH-:9].[Na+].[OH2:11]>>[N:1](=[C:3]([CH:6]([CH3:8])[CH3:7])[C:4]([OH:11])=[O:9])[OH:2]

Participants

4

Reactant 3

HCID 962Water2×HCID 14798Sodium HydroxideHCID 73183566HCID 73183566, compound

Product 1

HCID 73164534HCID 73164534, compound

Procedure

A solution of 3.36 g of 2-oximino-3-methylbutyronitrile, 7 ml of 50% NaOH and 3 ml of water is refluxed under a slow stream of nitrogen for several hours. This is allowed to cool to RT. The mixture is then diluted with water and washed with ether to remove the neutrals. The aqueous layer is acidified and extracted into ether to give 2-oximino-3-methylbutanoic acid, m.p. =153° (dec).

Workup

  1. washwashed with ether
  2. customto remove the neutrals
  3. extractionextracted into ether

Sources & evidence

ORD record
ord-2e5605f71dd54f4588000309740a2510
Source dataset
uspto-grants-1981_11
Patent number
US04302402

Reaction notes

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