Ethanimidic acid, ethyl ester, hydrochloride (1:1) → HCID 178432593, compound

Participants

Reaction Steps

A mixture of 1.0 g. (4 mmoles) of 2-(2-dimethylamino-4-pyridyl)-2,2-diethoxyethylamine, 500 mg. (4.1 mmoles) of ethyl acetimidate hydrochloride and 15 ml. of ethanol is heated to reflux for 1.5 hours. The mixture is concentrated, and the residue taken up in 10 ml. of concentrated hydrochloric acid. After heating at steam bath temperatures for 1 hour, the cooled acid solution is made basic by the addition of solid sodium carbonate, and the product is extracted with chloroform (3×10 ml.). The combined extracts are dried and concentrated to give the crude product, which is purified further by chromatographing on silica-gel using chloroform-methanol as the eluent.

Provenance & Evidence