Dimethyl Sulfoxide → HCID 86733200, compound

HRID 1155583Notes

Reaction equation

HRID 1155583 reaction equation
O.[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][S:5](=[O:8])([OH:7])=[O:6].[CH3:12][S:13]([CH3:15])=[O:14]>CC(C)=O>[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][S:5](=[O:7])([OH:8])=[O:6].[CH3:12][S:13]([CH3:15])=[O:14]

Participants

4

Reactant 2

HCID 679Dimethyl SulfoxideHCID 12308854L-Cysteic acid monohydrate

Product 1

HCID 86733200HCID 86733200, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

One and one-tenth grams of L-cysteic acid monohydrate was treated with 4 ml of DMSO. It slowly dissolved with swirling and some heating. Five ml of acetone was then added with swirling. Toward the end of this addition, a crystallization set in. After a period, 2 ml more of acetone were added. Then, after cooling with ice, the crystalline product was filtered off. Obtained 1.37 g of L-cysteic acid-DMSO molecular compound (yield, 94%). This sintered at 160° C. then gradually decomposed on heating to 180° C.

Workup

  1. dissolutionIt slowly dissolved
  2. additionToward the end of this addition
  3. customa crystallization
  4. waitAfter a period
  5. addition2 ml more of acetone were added
  6. temperatureThen, after cooling with ice
  7. filtrationthe crystalline product was filtered off

Sources & evidence

ORD record
ord-8e83a8206eaa4b098f942272ca5b3721
Source dataset
uspto-grants-1981_11
Patent number
US04302593

Reaction notes

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