1-Benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl)urea → N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea

HRID 1155646Notes

Reaction equation

HRID 1155646 reaction equation
C([NH:9][C:10]([NH:12][CH:13]1[C:21]2[CH:20]=[CH:19][S:18][C:17]=2[CH2:16][CH2:15][CH2:14]1)=[O:11])(=O)C1C=CC=CC=1.C([NH:30][C:31]([NH:33][CH:34]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37][CH2:36][CH2:35]1)=[O:32])(=O)C1C=CC=CC=1>>[S:18]1[CH:19]=[CH:20][C:21]2[CH:13]([NH:12][C:10]([NH2:9])=[O:11])[CH2:14][CH2:15][CH2:16][C:17]1=2.[CH:34]1([NH:33][C:31]([NH2:30])=[O:32])[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37][CH2:36][CH2:35]1

Participants

4

Reactant 2

HCID 130370061-Benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl)ureaHCID 205373051-Benzoyl-3-(1,2,3,4-tetrahydro-1-naphthyl)urea

Product 2

HCID 13036998N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)ureaHCID 13037020(1,2,3,4-Tetrahydronaphthalen-1-yl)urea

Procedure

In the manner described in Example 60, 1-benzoyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea and 1-benzoyl-3-(1,2,3,4-tetrahydro-1-naphthyl)urea are hydrolyzed to afford 4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea, m.p. 204.5° C. to 208.5° C., and 1,2,3,4-tetrahydro-1-naphthylurea, m.p. 212° C. to 214° C.

Sources & evidence

ORD record
ord-d99b7bb06faa4082843f6cea5c29747b
Source dataset
uspto-grants-1982_06
Patent number
US04332724

Reaction notes

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