Phosgene → HCID 20537582, compound

Participants

Reaction Conditions

Reaction Steps

After dilution with 200 ml of tetrahydrofurane, 34 g of 3-amino-1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione hydrobromide (obtained in Example 2b) are added at -20° C. to 104 ml of a 20% solution of phosgene in toluene. Then 27.9 g of triethylamine in 100 ml of tetrahydrofurane are added dropwise at -37° to -28° C. and the reaction mixture is thereafter stirred for a further 12 hours at -33° C. to bring the reaction to completion. The precipitate is collected by filtration at -20° C. and the solution is concentrated. The 3-(N-chlorocarbonylamino)-1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione obtained is used direct for the consequent reaction.

Provenance & Evidence