HCID 20537491, compound → HCID 20537472, compound

Participants

Reaction Steps

A solution of 10 g of the product of Example 25 in 300 ml of 1 N hydrochloric acid was refluxed for 6 hours and was then cooled to room temperature and was diluted with 300 ml of water. The mixture was extracted with ethyl acetate and the organic phase was washed with aqueous sodium chloride and evaporated to dryness under reduced pressure. The 9.1 g of residue were chromatographed over silica gel and eluted with a 95-5 chloroform-methanol mixture to obtain 5.4 g of 4-[1-cyclopropylmethyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-indole with an Rf=0.10.

Provenance & Evidence