HCID 12811127, compound → HCID 178426988, compound

HRID 1155706Notes

Reaction equation

HRID 1155706 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)[N:5]=[C:4]([C:17]([OH:19])=O)[CH:3]=1.[NH2:20][C:21]1[NH:25][N:24]=[N:23][N:22]=1>S(Cl)(Cl)=O>[NH:22]1[C:21]([NH:20][C:17]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([C:8]3[CH:9]=[CH:10][C:11]([N+:14]([O-:16])=[O:15])=[CH:12][CH:13]=3)[N:5]=2)=[O:19])=[N:25][N:24]=[N:23]1

Participants

4

Reactant 2

HCID 12811127HCID 12811127, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178426988HCID 178426988, compoundYield 66.2%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

In the same manner as described in Example 13-(1), 4-methyl-6-(4-nitrophenyl)-2-pyridinecarboxylic acid (3.0 g), thionyl chloride (20 ml) and 5-aminotetrazole (1.29 g) are reacted to give N-(5-tetrazolyl)-4-methyl-6-(4-nitrophenyl)-2-pyridinecarboxamide (2.5 g). M.P. 284°-285° C. (decomp.) (wetted from 278° C.) (recrystallized from dimethylformamide-ethanol)

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-7e6c8a369bd34febb2bd7ac371b5e151
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

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