HCID 12811130, compound → HCID 178426986, compound

HRID 1155707Notes

Reaction equation

HRID 1155707 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=2)[N:5]=[C:4]([C:17]([OH:19])=O)[CH:3]=1.[NH2:20][C:21]1[NH:25][N:24]=[N:23][N:22]=1>S(Cl)(Cl)=O>[NH:22]1[C:21]([NH:20][C:17]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=3)[N:5]=2)=[O:19])=[N:25][N:24]=[N:23]1

Participants

4

Reactant 2

HCID 12811130HCID 12811130, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178426986HCID 178426986, compoundYield 50.8%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

In the same manner as described in Example 13-(1), 4-methyl-6-(3-nitrophenyl)-2-pyridinecarboxylic acid (3.0 g), thionyl chloride (30 ml) and 5-aminotetrazole (1.2 g) are reacted to give N-(5-tetrazolyl)-4-methyl-6-(3-nitrophenyl)-2-pyridinecarboxamide (1.92 g). M.P. 288°-290° C. (decomp.) (recrystallized from dimethylformamide)

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-0ca42fb1ef434ebb9c1be6be77bfc3a0
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

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