Thionyl Chloride → HCID 178439309, compound

HRID 1155708Notes

Reaction equation

HRID 1155708 reaction equation
[CH:1]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=2)[N:7]=[C:6]([C:19]([OH:21])=O)[CH:5]=1)([CH3:3])[CH3:2].S(Cl)(Cl)=O.[NH2:26][C:27]1[NH:31][N:30]=[N:29][N:28]=1>>[NH:28]1[C:27]([NH:26][C:19]([C:6]2[CH:5]=[C:4]([CH:1]([CH3:2])[CH3:3])[CH:9]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=3)[N:7]=2)=[O:21])=[N:31][N:30]=[N:29]1

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 12811131HCID 12811131, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178439309HCID 178439309, compoundYield 42.5%

Procedure

In the same manner as described in Example 13-(1), 4-isopropyl-6-(4-nitrophenyl)-2-pyridinecarboxylic acid (1.62 g), thionyl chloride (15 ml) and 5-aminotetrazole (0.63 g) are reacted to give N-(5-tetrazolyl)-4-isopropyl-6-(4-nitrophenyl)-2-pyridinecarboxamide (0.85 g). M.P. 270°-272° C. (decomp.) (recrystallized from dimethylformamide-ethanol)

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-334cecd0313d452d8020412dcc57c5f7
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

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