Thionyl Chloride → HCID 178441078, compound

HRID 1155709Notes

Reaction equation

HRID 1155709 reaction equation
[CH2:1]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)[N:8]=[C:7]([C:20]([OH:22])=O)[CH:6]=1)[CH2:2][CH2:3][CH3:4].S(Cl)(Cl)=O.[NH2:27][C:28]1[NH:32][N:31]=[N:30][N:29]=1>>[NH:29]1[C:28]([NH:27][C:20]([C:7]2[CH:6]=[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH:10]=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=3)[N:8]=2)=[O:22])=[N:32][N:31]=[N:30]1

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 12811132HCID 12811132, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178441078HCID 178441078, compoundYield 55.8%

Procedure

In the same manner as described in Example 13-(1), 4-n-butyl-6-(4-nitrophenyl)-2-pyridinecarboxylic acid (1.7 g), thionyl chloride (15 ml) and 5-aminotetrazole (0.67 g) are reacted to give N-(5-tetrazolyl)-4-n-butyl-6-(4-nitrophenyl)-2-pyridinecarboxamide (1.16 g). M.P. 278°-280° C. (decomp.) (recrystallized from dimethylformamide-ethanol)

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-bfc778c2c066439c98577d55d1fe69ff
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

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