HCID 12784986, compound → HCID 178492686, compound

HRID 1155710Notes

Reaction equation

HRID 1155710 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[N:6]=[C:5]([C:18]([OH:20])=O)[CH:4]=1.[NH2:21][C:22]1[NH:26][N:25]=[N:24][N:23]=1>S(Cl)(Cl)=O>[NH:23]1[C:22]([NH:21][C:18]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([C:9]3[CH:10]=[CH:11][C:12]([N+:15]([O-:17])=[O:16])=[CH:13][CH:14]=3)[N:6]=2)=[O:20])=[N:26][N:25]=[N:24]1

Participants

4

Reactant 2

HCID 12784986HCID 12784986, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178492686HCID 178492686, compoundYield 65.8%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

In the same manner as described in Example 13-(1), 4-methoxy-6-(4-nitrophenyl)-2-pyridinecarboxylic acid (2.54 g), thionyl chloride (30 ml) and 5-aminotetrazole (1.2 g) are treated to give N-(5-tetrazolyl)-4-methoxy-6-(4-nitrophenyl)-2-pyridinecarboxamide (2.08 g). M.P. 279°-281° C. (decomp.) (recrystallized from dimethylformamide)

Workup

  1. additionare treated

Sources & evidence

ORD record
ord-131830c0dcb945118cb7cb1046f83293
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

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