p-Fluoronitrobenzene → HCID 20537894, compound

Participants

Reaction Steps

Following the procedure of Example 1, 5-chloro-2-pyridinemethanol, prepared from 5-chloropicolinic acid, is reacted with 1-fluoro-4-nitrobenzene to give 5-chloro-2-(4-nitrophenoxy)methylpyridine, which is converted to 5-chloro-2-(4-aminophenoxy)methylpyridine by reduction with iron and ammonium chloride. The 5-chloro-2-(4-aminophenoxy)methylpyridine and 3,4,5,6-tetrahydrophthalic anhydride are reacted to yield the final product N-4-[2-(5-chloropyridyl)methoxy]phenyl-3,4,5,6-tetrahydrophthalimide.

Provenance & Evidence