Sodium Hydroxide → Sodium alpha-[4-(4-Trifluoromethylphenoxy)phenoxy]propionate

HRID 1155789Notes

Reaction equation

[F:1][C:2]([F:23])([F:22])[C:3]1[CH:21]=[CH:20][C:6]([O:7][C:8]2[CH:19]=[CH:18][C:11]([O:12][CH:13]([CH3:17])[C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[OH-].[Na+:25]>C(O)C.O>[F:1][C:2]([F:22])([F:23])[C:3]1[CH:4]=[CH:5][C:6]([O:7][C:8]2[CH:19]=[CH:18][C:11]([O:12][CH:13]([CH3:17])[C:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)=[CH:20][CH:21]=1.[Na+:25]

Participants

Conditions

Temperature: 90 °C

Procedure

32.6 g of α-[4-(4-trifluoromethylphenoxy)phenoxy]-propionic acid was dissolved in 30 ml of ethanol, and an aqueous solution of 4.0 g of sodium hydroxide in 40 ml of water was added. The mixture was maintained at 70° to 75° C. for 1 hour. Then, ethanol and water were removed from the reaction product at reduced pressure. The residue was heated at 90° C. for 4 hours to afford 34.1 g (yield: 98%) of the final product as a white solid.

Workup

temperatureThe mixture was maintained at 70° to 75° C. for 1 hour
customThen, ethanol and water were removed from the reaction product at reduced pressure

Sources & evidence

ORD record: ord-d24a56f8347a40fd9f3a8592fac002a7
Source dataset: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04332961

Reaction notes

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