反应详情

A mixture of 8.5 g. (17.03 mmols) of 1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-3-hydroxypiperidine, 2.0 g. of 10% palladium-on-carbon and 60 ml. of ethanol is stirred under one atmosphere of hydrogen for 2 hours. The reaction mixture is filtered through diatomaceous earth with ethyl acetate and evaporated. The residue is recrystallized from ethyl acetate to yield 3.8 g. (70%) of the title compound. A second crop of the title compound 0.396 g. (7%) is obtained from the mother liquor.

1. additionA mixture of 8.5 g
2. filtrationThe reaction mixture is filtered through diatomaceous earth with ethyl acetate
3. customevaporated
4. customThe residue is recrystallized from ethyl acetate
5. customto yield 3.8 g