HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-1,2,5,6-tetrahydropyridine | HCID 15571561 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]piperidine | HCID 15571558 | 62% |
Reaction Steps
A mixture of 7.4 g. (24.5 mmoles) of 3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-1,2,5,6-tetrahydropyridine and 2.0 g. of 10% palladium-on-carbon in 150 ml. of ethanol and 75 ml. of ethyl acetate is stirred under one atmosphere of hydrogen for 2.5 hours. The reaction is filtered through diatomaceous earth and evaporated. Crystallization of the residue from ether-pentane gave 4.6 g. (62%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04332942 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-4aea9a63763e459ea2ac3187addec0e0 |
| Source note | uspto-grants-1982_06 |