HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinic acid → 4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Reactant | ethyl 2-amino-5-phenylthiophene-3-carboxylate | HCID 638860 | — |
| Product | 4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid | HCID 12862355 | 6.2% |
Reaction Steps
From 5.0 g (0.02 mol) of 2-amino-5-phenyl-3-thiophenecarboxylic acid, ethyl ester (Chemische Berichte, Vol. 99, pages 94-100, 1966) and 3.2 g (0.02 mol) of 6-chloro-3-pyridinecarboxylic acid (Aldrich Chemical Company), following the procedure of Example 3, there is obtained 0.4 g of 4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno-[2,3-d]pyrimidine-7-carboxylic acid; mp 387°-392° C. after recrystallization from pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04332947 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-101e8a0c115b42b1a64f0c6dc5879d68 |
| Source note | uspto-grants-1982_06 |