HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinic acid → 2-Methyl-10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Reactant | 3-Amino-5-methyl-thiophene-2-carboxylic acid methyl ester | HCID 818952 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methyl-10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxylic acid | HCID 12953052 | — |
Reaction Steps
A mixture of 1.7 g (0.01 mol) of 3-amino-5-methyl-2-thiophenecarboxylic acid, methyl ester (German Pat. No. 1055007, Apr. 16, 1959) and 1.6 g (0.01 mol) of 6-chloro-3-pyridinecarboxylic acid (Aldrich Chemical Company) is heated in an oil bath at 180° C. for two hours. The mixture is cooled, dissolved in hot methanol, cooled and 0.23 g of 2-methyl-10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxylic acid is collected; mp 338°-340° C. after recrystallization from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04332947 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-921a81eb7df8469a89c9ca1341005d7b |
| Source note | uspto-grants-1982_06 |