4-methylquinazolin-2-amine → HCID 20536262, compound

HRID 1155941Notes

Reaction equation

HRID 1155941 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[Cl:13][C:14]1[C:19]([S:20]([N:23]=[C:24]=[O:25])(=[O:22])=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=1>C(Cl)Cl>[Cl:13][C:14]1[C:19]([S:20]([NH:23][C:24]([NH:1][C:2]2[N:11]=[C:10]([CH3:12])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[O:25])(=[O:21])=[O:22])=[CH:18][CH:17]=[CH:16][N:15]=1

Participants

4

Reactant 2

HCID 2693254-methylquinazolin-2-amineHCID 130384352-Chloro-3-pyridinesulfonylisocyanate

Product 1

HCID 20536262HCID 20536262, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a dry, stirred solution of 8.0 g of 2-amino-4-methylquinazoline in 200 ml of methylene chloride at ambient temperature and pressure is added 13 g of 2-chloropyridin-3-sulfonylisocyanate. The resulting mixture is stirred at reflux for 2 hours and then concentrated at reduced pressure. The residue is triturated with 1-chlorobutane and filtered to yield the desired solid product.

Workup

  1. temperatureat reflux for 2 hours
  2. concentrationconcentrated at reduced pressure
  3. customThe residue is triturated with 1-chlorobutane
  4. filtrationfiltered
  5. customto yield the desired solid product

Sources & evidence

ORD record
ord-633077aea5064e9289477acfd2d10f90
Source dataset
uspto-grants-1982_06
Patent number
US04333760

Reaction notes

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