Hydrochloric Acid → 2-Acetyl-N-[(4-methylquinazolin-2-yl)aminocarbonyl]benzenesulfonamide

Participants

Reaction Steps

A mixture containing 0.86 g of N-[(4-methylquinazolin-2-yl)aminocarbonyl]-2-carboxybenzenesulfonamide in 50 ml of anhydrous tetrahydrofuran is treated with 40 ml of a 1.4 M solution of methyllithium in ether at 25° under a nitrogen atmosphere. The mixture is stirred for 4 hours at ambient temperature and then poured into 500 ml of water containing 10 ml of concentrated hydrochloric acid. The product can be isolated by extraction into methylene chloride followed by evaporation and if necessary, can be purified by preparative thin layer chromatography and/or recrystallization.

Provenance & Evidence