HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 5-Bromo-3,3-dimethylbenzofuran-2(3H)-one | HCID 16220634 | — |
| Product | 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran-2-one | HCID 20536247 | 45% |
Reaction Steps
5-Bromo-2,3-dihydro-3,3-dimethylbenzofuran-2-one (39.2 g, 0.162 mole) was treated with cuprous cyanide (17.9 g, 0.2 mole) in dimethyl formamide (40 ml) (as in example 2). Recrystallisation (twice) of the product from ethanol yielded 14 g (45%) title product m.p. 138°-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333759 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-0752ff598b194c4ab962419e8838d10a |
| Source note | uspto-grants-1982_06 |