HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-(2-Methoxyphenyl)-2-methylpropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (2-Methoxyphenyl)acetonitrile | HCID 81496 | — |
| Product | 2-(2-Methoxyphenyl)-2-methylpropanenitrile | HCID 10197920 | 85% |
Reaction Steps
By a method analogous to that of Example 3(a), o-methoxybenzyl cyanide was methylated with methyl iodide and sodium hydride in dimethylformamide to give the desired compound in 85% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333759 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-c455276a076849faa4af107f42988fb5 |
| Source note | uspto-grants-1982_06 |