HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 4-Bromo-2-(2-chloro-1,1-dimethylethyl)anisole | HCID 4605778 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Solvent | Quinoline | HCID 7047 | — |
| Product | 5-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran | HCID 5323595 | — |
Reaction Steps
2-(2-Methoxy-5-bromophenyl)-2-methyl-1-chloropropane (from example 5(a)) (120 g, 0.43 mole) was heated under reflux (163°-9° C.) with pyridine hydrochloride (220 g) in quinoline (220 g) with stirring for 3 hours. Addition to iced dilute hydrochloric acid and isolation through ether gave after distillation 73 g (75%) title product b.p. 62°-4° C. at 0.01 mm Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333759 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-035e966c881d4a4aa855b64c05ea836b |
| Source note | uspto-grants-1982_06 |