Water → HCID 20536216, compound

HRID 1155969Notes

Reaction equation

HRID 1155969 reaction equation
[S:1](Cl)(Cl)=[O:2].[C:5]([C:7]1[CH:8]=[CH:9][C:10]([OH:18])=[C:11]([C:13]([CH3:17])([CH3:16])[CH2:14][OH:15])[CH:12]=1)#[N:6].N1C=CC=CC=1.O>C(OCC)C>[C:5]([C:7]1[CH:8]=[CH:9][C:10]2[O:18][S:1](=[O:2])[O:15][CH2:14][C:13]([CH3:16])([CH3:17])[C:11]=2[CH:12]=1)#[N:6]

Participants

6

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 24386Thionyl ChlorideHCID 20536186HCID 20536186, compound

Product 1

HCID 20536216HCID 20536216, compoundYield 32.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Thionyl chloride (4.2 g) in diethyl ether (10 ml) was added dropwise with stirring at 0°-5° C. to a solution of 2-(5-cyano-2-hydroxyphenyl)-2-methyl-1-propanol (5 g) prepared as in Example 26, and pyridine (5.5 g) in diethyl ether (80 ml). The mixture was stirred for 3 hours at 0°-20° C. Water was then added and the mixture was filtered. The ether solution was then washed with dilute hydrochloric acid, then with aqueous sodium bicarbonate and water (twice), then dried over magnesium sulphate and run down. The residue was recrystallised from ethanol, giving the title product (2.0 g) as white crystals, mp 87°-88° C.

Workup

  1. filtrationthe mixture was filtered
  2. washThe ether solution was then washed with dilute hydrochloric acid
  3. dry with materialwith aqueous sodium bicarbonate and water (twice), then dried over magnesium sulphate
  4. customThe residue was recrystallised from ethanol

Sources & evidence

ORD record
ord-eade94f5bb36436b84a369668f88f5c4
Source dataset
uspto-grants-1982_06
Patent number
US04333759

Reaction notes

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